Publications
Browse by Year:
2024
  • VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
    Wang C.C.¶, Zhang K., Cai B., Jillian E.H., Kathryn E.C., Hu J.J., Zhao C.Y., Tian Z.Q., Hu X., Daniel Hall., Qiang J.L., Hou S.Q., Liu Z.Y., Gu J.G., Zhang Y.Y., Kim B.S., Jacqueline B., Fang Y.S., Liu C., Axel T.B., Li Dan.*, Diao J.J.*
    Nat Cell Biol., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex

    Zhao Y.L.¶, Guo L.J.¶, Hu J.J.¶, Ren Z.Y., Li Y.N., Hu M., Zhang X., Bi L.L., Li D.,

    Ma H.H., Liu C.*, Sun Bo.*

    Nucleic Acids Res., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Hsp90α forms condensate engaging client proteins with RG motif repeats
    Hu J.J.*¶, Dong H., Li Y.C., Gu J.G., Yang L., Si C.F., Zhang Y.Y., Li T.T., Li D.*, Liu C.*
    Chem Sci
    ., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Lysophosphatidylcholine binds α-synuclein and prevents its pathological 

    aggregation

    Zhao C.Y.¶, Tu J.¶, Wang C.C.¶, Liu W.B., Gu J.G., Yin Y.D., Zhang S.N., Li D., Diao J.J.*, Zhu Z.J.*, Liu C.*
    Natl Sci Rev.
    , 2024. (¶co-first author, *corresponding author)
    Full Article
  • Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

    Mao X.¶, Gu H.¶, Kim D.¶, Kimura Y., Wang N., Xu E., Kumbhar R., Ming X., 

    Wang H., Chen C., Zhang S., Jia C., Liu Y., Bian H., Karuppagounder SS., Akkentli F., 

    Chen Q., Jia L., Hwang H., Lee SH., Ke X., Chang M., Li A., Yang J., Rastegar C., 

    Sriparna M., Ge P., Brahmachari S., Kim S., Zhang S., Shimoda Y., Saar M., Liu H., 

    Kweon SH., Ying M., Workman CJ., Vignali DAA., Muller UC., Liu C., Ko HS.*, 

    Dawson VL.*, Dawson TM.*

    Nat Commun., 2024. (¶co-first author, *corresponding author)

    Full Article
  • A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain
    Zhao Q.Y.¶, Fan Y.¶, Zhao W.B., Ni Y., Tao Y.Q., Bian J., Xia W.C., Yu W.B., Fan Z.,
    Liu C., Sun B., Le W.D., Li W.S., Wang J.*, Li D.*
    Cell Discov., 2024. (¶co-first author, *corresponding author)
    Full Article
  • A phase-separated protein hub modulates resistance to Fusarium head blight in wheat
    He Y.¶, Yang X.J.¶, Xia X.B.¶, Wang Y.H., Dong Y.F., Wu L., Jiang P., Zhang X., Jiang C., Ma H.X., Ma W.J., Liu C., Ryan W., Matthew R.T., Zhang Z.G., Li G.*
    Cell Host Microbe., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
    Hu J.J.¶, Xia W.C.¶, Zeng S.Y.¶, Lim  Y.J.¶, Tao Y.Q., Sun Y.P., Zhao L., Wang H.S.,
    Le W.D., Li D., Zhang S.N., Liu C.*, Li Y.M.*
    Nat Commun., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus 
    Zhang H.¶, Guo H.Z., Li D.N., Zhang Y.L., Zhang S.Q., Kang W.Y., Liu C., Le W.D.,
    Wang L.*, Li D.*, Dai B.*
    Nat Commun., 2024. (¶co-first author, *corresponding author)
    Full Article
  • N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
    Wang C.¶, Zhao C.¶, Hu X., Qiang J., Liu Z., Gu J., Zhang S., Li D., Zhang Y., Burré J., Diao J.*, Liu C.*
    bioRxiv., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions
    Hou S.¶, Hu J.J.¶, Yu Z.W., Li D, Liu C.*, Zhang Y.*
    Nat Commun., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies

    Zhao W.B.¶, Liu K.E.¶, Fan Y.¶, Zhao Q.Y., Tao Y.Q., Zhang M.W., Gan L.H., Yu W.B., 

    Sun B., Li D., Liu C.*, Wang J.*

    Cell Discov., 2024. (¶co-first author, *corresponding author)
    Full Article
  • Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure
    Jiang Y.Q.¶, Gu J.G.¶, Niu X.D.¶, Hu J.J., Zhang Y.Z., Li D., Tang Y.D., Liu C.*, Li Z.J.*
    Circulation., 2024. (¶co-first author, *corresponding author)
    Full Article
2023
  • Advanced Techniques for Detecting Protein Misfolding and Aggregation in
    Cellular Environments
    Bai Y.L.¶, Zhang S.N.¶, Dong H.¶, Liu Y., Liu C.*, Zhang X.*
    Chem Rev., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Molecular rules governing the structural polymorphism of amyloid fibrils in
    neurodegenerative diseases
    Li D.*, Liu C.*
    Structure., 2023. (*corresponding author)
    Full Article
  • Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle
    clustering

    Lai Y.¶, Zhao C.Y.¶, Tian Z.Q.¶, Wang C.C.¶, Fan J.Q.¶, Hu X., Tu J., Li T.H.,
    Leitz Jeremy., Pfuetzne R.A., Liu Z.T., Zhang S.N., Su Z.M., Burré J., Li D.,
    Südhof Thomas.C., Zhu Z.J., Liu C.*, Brunger Axel.T.*, Diao J.J.*

    Proc Natl Acad Sci U S A., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Creating an Amyloid 'Kaleidoscope' Using Short Iodinated Peptides
    Li D.N.¶, Ma Y.Y.¶, Xia W.C., Tao Y.Q., Zhang Y.L., Zhang H., Li D., Dai B.*, Liu C.*
    Angew Chem Int Ed Engl., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Engineering of antimicrobial peptide fibrils with feedback degradation of 
    bacterial-secreted enzymes
    Wang F.H.¶, Xia W.C.¶, Zhang M.M., Wu R.R., Song X.L., Hao Y., Feng Y.H., 
    Zhang L.W., Li D., Kang W.Y., Liu C.*, Liu L.* 
    Chem Sci., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Rational design of functional amyloid fibrillar assemblies

    Wang X.Y.¶, Zhang S.N.¶, Zhang J.C., Wang Y.M., Jiang X.Y., Tao Y.Q., Li D., 

    Zhong C.*, Liu C.*

    Chem Soc Rev., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
    Xiang J.¶, Tao Y.Q.¶, Xia Y.Y.¶, Luo S.L., Zhao Q.Y., Li B.W., Zhang X.Q., Sun Y.P., Xia W.C., Zhang M.M., Kang S.S., Ahn E.H., Liu X., Xie F., Guan Y.H., Yang J.J., Bu L,H., Wu S.X., Wang X.C., Cao X.B., Liu C., Zhang Z.T.*, Li D.*, Ye K.Q.*
    Cell., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Structural mechanism for specific binding of chemical compounds to amyloid
    fibrils

    Tao Y.Q.¶, Xia W.C.¶, Zhao Q.Y.¶, Xiang H.J., Han C., Zhang S.Q., Gu W., 

    Tang W.J, Li Y., Tan L., Li D.*, Liu C.*

    Nat Chem Biol., 2023. (¶co-first author, *corresponding author)

    Full Article
  • β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology 
    and cognitive deficits in Alzheimer's disease model mice
    Zhao Y.N.¶, Zheng Q.Y., Hong Y.J., Gao Y., Hu J.J., Lang M.J., Zhang H.F., Zhou Y., 
    Luo H., Zhang X., Sun H., Yan X.X., Huang T., Wang Y.J., Xu H., Liu C., Wang X.*
    Nat Neurosci., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Protein amyloid aggregate: Structure and function
    Xu Q.H.¶, Ma Y.Y.¶, Sun Y.P.¶, Li D., Zhang X., Liu C.* 
    Aggregate.
    , 2023. (¶co-first author, *corresponding author)
    Full Article
  • Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions 
    in nucleocapsid-like assembly
    Wang Y.¶, Ling X.B.¶, Zhang C., Zou J., Luo B.N., Luo Y.B., Jia X.Y., Jia G.W., 
    Zhang M.H., Hu J.C., Liu T., Wang Y.F.Y., Lu K.F., Li D., Ma J.B.*, Liu C.*, Su Z.M.*
    Mol Biomed., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent 
    Abnormal Phase Transition of Fused in Sarcoma Protein
    Zhang H.¶, Gu J.G., Zhang Y.L., Guo H.Z., Zhang S.N., Song J., Liu C., Wang L.*, 
    Li D.*, Dai B.*
    ACS Nano., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Emerging roles of O-glycosylation in regulating protein aggregation, phase 
    separation, and functions
    Li X.¶, Lv P.¶, Du Y.F.¶, Xing C.*, Liu C.*
    Curr Opin Chem Biol.
    , 2023. (¶co-first author, *corresponding author)
    Full Article
  • Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding 
    Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based 
    Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy
    Zhang S.N.¶, Li J.¶, Xu Q.H.¶, Xia W.C., Tao Y.Q., Shi C.W., Li D., Xiang S.Q.*, Liu C.*
    J Am Chem Soc.
    , 2023. (¶co-first author, *corresponding author)
    Full Article
  • Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis 
    elegans
    Wang F.R.¶, Jin T.¶, Li H.Y.¶, Long H.F., Liu Y., Jin S., Lu Y.Y., Peng Y.H., Liu C.
    Zhao L.H.*, Wang X.H.* 
    FASEB J., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates 
    α-synucleinopathy in rat brain
    Yang Z.F.¶, Wang Y.¶, Wei M., Li S., Jia C.C., Cheng C., Nusaif M., Zhang J., Liu C.
    Le W.D.*
    Cell Death Dis., 2023. (¶co-first author, *corresponding author)
    Full Article
2022
  • Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases
    Zhang S.Q.¶, Dong H.¶, Bian J.¶, Li D., Liu C.*
    Fundamental Research.
    , 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease
    Fan Y.¶, Sun Y.P.¶, Yu W.B., Tao Y.Q., Xia W.C., Liu Y.Q., Zhao Y.Q., Tang Y.L., Sun Y.M., Liu F.T., Cao Q., Wu J.J., Liu C., Wang J.*, Li D.*
    Structure., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Subtle change of fibrillation condition leads to substantial alteration of 
    recombinant Tau fibril structure
    Li X.¶, Zhang S.Q.¶, Liu Z.T.¶, Tao Y.Q., Xia W.C., Sun Y.P., Liu C., Le W.D., Sun B., 
    Li D.*
    iScience., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular 
    integrity and mitigates acute lung injury
    He H.¶, Yang W.¶, Su N.¶, Zhang C.K., Dai J.N., Han F., Singhai M., Bai W.J., Zhu X.L., Zhu J., Liu Z., Xia W.C., Liu X.T., Zhang C.H., Jiang K., Huang W.H., Chen D., 
    Wang Z.Y., He X.Y., Kirchhoff F., Li Z.Y., Liu C., Huan J.N., Wang X.H., Wei W., 
    Wang J., Augustin H.G., Hu J.H.*
    J Exp Med., 2023. (¶co-first author, *corresponding author)
    Full Article
  • Global profiling of arginine dimethylation in regulating protein phase separation 
    by a steric effect-based chemical-enrichment method
    Wang Q.¶, Li Z.X.¶, Zhang S.Q.¶, Li Y.C., Wang Y., Fang Z., Ma Y.N., Liu Z., Li D., 
    Liu C.*, Ye M.L.*
    Proc. Natl. Acad. Sci. U S A., 2022. (¶co-first author, *corresponding author)
    Full Article
  • A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation
    Li Y.C., Gu J.G., Liu C., Li D.*
    Methods in Molecular Biology., 2022 (*corresponding author)
    Full Article
  • Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of 
    microglia
    Long H.F.¶, Zhang S.N.¶, Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*
    Cell Rep., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Non-ergodicity of a globular protein extending beyond its functional timescale
    Li J.¶, Xie J.F., Godec A., Weninger K.R., Liu C., Smith J.C., Hong L.*
    Chem Sci., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation 
    and liquid-to-gel transition
    Lu S.¶, Hu J.J., Arogundade O.A., Goginashvili A., Vazquez-Sanchez S., Diedrich J.K., Gu J.G., Blum J., Oung S., Ye Q.Z., Yu H.Y., Ravits J., Liu C., Yates J.R., 
    Cleveland D.W.*
    Nat Cell Biol. 2022. (¶co-first author, *corresponding author)
    Full Article
  • Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau 
    aggregation-induced pathology
    Zhang S.N.¶, Zhu Y.¶, Lu J.X.¶, Liu Z.Y., Lobato A.G., Zeng W., Liu J.Q., Zeng S.Y., 
    Liu C., Liu J., He Z.H., Zhai R.G.*, Li D.*
    Elife., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Bloom Syndrome Helicase Compresses Single‐Stranded DNA into 
    Phase‐Separated Condensates
    Wang T.¶, Hu J.J.¶, Li Y.N., Bi L.L., Guo X.S., Zhang X., Li D., Hou X.M., Modesti M., 
    Xi X.G., Liu C.*, Sun B.*
    Angew Chem Int Ed Engl., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Stochastically multimerized ParB orchestrates DNA assembly as unveiled by 
    single-molecule analysis
    Guo J.L.¶, Zhao Y.L.¶, Zhang Q., Feng Y., Zhang X., Wang T., Liu C., Ma H.H., Sun B.*
    Nucleic Acids Res., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Heparin induces α-synuclein to form new fibril polymorphs with attenuated 
    neuropathology
    Tao Y.Q.¶, Sun Y.P.¶, Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., 
    Liu C.*, Li D.*
    Nat Commun., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related 
    proteins in the nucleus
    Gao C.¶, Gu J.G., Zhang H., Jiang K., Tang L.L., Liu R., Zhang L., Zhang P.F., Liu C.*
    Dai B.*, Song H.*
    Cell Reports., 2022. (¶first author, *corresponding author)
    Full Article
  • Structural insights of Fe 3+ induced α-synuclein fibrillation in Parkinson's disease
    Zhao Q.Y.¶, Tao Y.Q.¶, Zhao K., Ma Y.Y., Xu Q.H., Liu C., Zhang S.N., Li D.*
    J Mol Biol., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion
    Wang L.Q.¶, Ma Y.Y.¶, Yuan H.Y.¶, Zhao K., Zhang M.Y., Wang Q., Huang X., Dai B., 
    Chen J., Li D., Zhang D.L., Wang Z.Z., Zou L.Y., Yin P., Liu C.*, Liang Y.*
    Nat. Commun., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation
    Li Y.C.¶, Gu J.G., Wang C., Hu J.J., Zhang S.Q., Liu C., Zhang S.N., Fang Y.S., Li D.*
    iScience., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Conformational strains of pathogenic amyloid proteins in neurodegenerative 
    diseases
    Li D.*, Liu C.*
    Nat Rev Neurosci.
    , 2022. (*corresponding author)
    Full Article
  • Cellular and animal models to investigate pathogenesis of amyloid aggregation 
    in neurodegenerative diseases
    Long H.F., Zeng S.Y., Li D.*
    Biophysics Reports., 2022. (*corresponding author)
    Full Article
  • Biochemical and biophysical characterization of pathological aggregation of 
    amyloid proteins
    Long H.F., Zeng S.Y., Sun Y.P., Liu C.*
    Biophysics Reports.
    , 2022. (*corresponding author)
    Full Article
  • Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation
    Song Y.X., Dai B., Wang Y., Wang Y., Liu C., Gourdon P., Liu L.*, Wang K.T.*, 
    Dong M.D.*
    Nano Lett., 2022. (*corresponding author)
    Full Article
  • Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance 
    in Arabidopsis
    Zhu S.B.¶, Gu J.G.¶, Yao J.J., Li Y.C., Zhang Z.T., Xia W.C., Wang Z., Gui X.R., Li L.T., 
    Li D., Zhang H.*, Liu C.*
    Developmental Cell.
    , 2022. (¶co-first author, *corresponding author)
    Full Article
  • A high-throughput method for exploring the parameter space of protein 
    liquid-liquid phase separation
    Li Y.C.¶, Gu J.G.¶, Liu C.*, Li D.*
    Cell Reports Physical Science., 2022 (¶co-first author, *corresponding author)
    Full Article
  • SARS-CoV-2 impairs the disassembly of stress granules and promotes 
    ALS-associated amyloid aggregation
    Li Y.C.¶, Lu S.Y.¶, Gu J.G.¶, Xia W.C., Zhang S.N., Zhang S.Q., Wang Y., Zhang C., 
    Sun Y.P., Lei J., Liu C., Su Z.M.*, Yang J.T.*, Peng X.Z.*, Li D.*
    Protein Cell., 2022. (¶co-first author, *corresponding author)
    Full Article
  • The mouse nicotinamide mononucleotide adenylyltransferase chaperones 
    diverse pathological amyloid client proteins
    Huang C.A.¶, Lu J.X.¶, Ma X.J.¶, Qiang J.L., Wang C.C., Liu C., Fang Y.S., Zhang Y.Y., 
    Li D.*, Zhang S.N.*
    J Biol Chem., 2022. (¶co-first author, *corresponding author)
    Full Article
  • Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease 
    dementia and normal elders
    Fan Y.¶, Zhao Q.Y.¶, Xia W.C.¶, Tao Y.Q., Yu W.B., Chen M.J., Liu Y.Q., Zhao J., 
    Sun Y.P., Si C.F., Zhang S.Q., Zhang Y.Y., Li W.S., Liu C.*, Wang J.*, Li D.*
    Cell Research., 2022.  (¶co-first author, *corresponding author)
    Full Article
  • Spatiotemporal dynamic regulation of membraneless organelles by chaperone 
    networks
    Li D.*, Liu C.*
    Trends in Cell Biology.
    , 2022. (*corresponding author)
    Full Article
2021
  • Molecular structure of an amyloid fibril formed by FUS low-complexity domain
    Sun Y.P.¶, Zhang S.Q.¶, Hu J.J.¶, Tao Y.Q., Xia W.C., Gu J.G., Li Y.C., Cao Q., Li D., 
    Liu C.*
    iScience.
    , 2021. (¶co-first author, *corresponding author)
    Full Article
  • Genetic prion disease–related mutation E196K displays a novel amyloid fibril 
    structure revealed by cryo-EM
    Wang L.Q.¶, Zhao K.¶, Yuan H.Y.¶, Dang H.B., Ma Y.Y., Wang Q., Wang C., Sun Y.P., Chen J., Li D., Zhang D.L., Yin P., Liu C.*, Liang Y.*
    Science Advances., 2021. (¶co-first author, *corresponding author)
    Full Article
  • The hereditary mutation G51D unlocks a distinct fibril strain transmissible to 
    wild-type α-synuclein
    Sun Y.P.¶, Long H.F.¶, Xia W.C., Wang K., Zhang X., Sun B., Cao, Q., Zhang Y.Y., 
    Dai B., Li D., Liu C.*
    Nat. Commun.
    , 2021. (¶co-first author, *corresponding author)
    Full Article
  • O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable 
    for Degradation
    Liu D.L.¶, Wei Q.J.¶, Xia W.C.¶, He C.D., Zhang Q.K., Huang L., Wang X.Y., Sun Y.P., 
    Ma Y.Y., Zhang X.H., Wang Y., Shi X.M., Liu C.*, Dong S.W.*
    J. Am. Chem. Soc., 2021. (¶co-first author, *corresponding author)
    Full Article
  • Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from 
    amyloid aggregation
    Gu J.G.¶, Wang C.¶, Hu R.F.¶, Li Y.C., Zhang S.N., Sun Y.P., Wang Q.Q., Li D., 
    Fang Y.S.*, Liu C.*
    Cell Research., 2021. (¶co-first author, *corresponding author)
    Full Article
  • Mechanistic basis for receptor-mediated pathological α-synuclein fibril 
    cell-to-cell transmission in Parkinson's disease
    Zhang S.N.¶, Liu Y.Q.¶, Jia C.Y.¶, Lim Y.J.¶, Feng G.Q.¶, Xu E.Q.,  Long H.F., 
    Yasuyoshi Kimura, Tao Y.Q., Zhao C.Y., Wang C.C., Liu Z.Y., Hu J.J., Ma M.R., 
    Liu Z.J., Lin J., Li D., Wang R.X., Valina L Dawson, Ted M Dawson*, Li Y.M.*, 
    Mao X.B.*, Liu C.*
    Proc. Natl. Acad. Sci. U S A.
    , 2021.  (¶co-first author, *corresponding author)

    Full Article
  • Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding
    Long H.F.¶, Zheng W.T.¶, Liu Y., Sun Y.P., Zhao K., Liu Z.Y., Xia W.C., Lv S.R., Liu Z.T., Li D., He K.W.*, Liu C.*
    Proc. Natl. Acad. Sci. U S A.
    , 2021.  (¶co-first author, *corresponding author)
    Full Article
  • The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3
    Wu X.L.¶, Ma Y.Y.¶, Zhao K.¶, Zhang J., Sun Y.P., Li Y.C., Dong X.Q., Hu H., Liu J., 
    Wang J., Zhang X., Li B., Wang H.Y., Li D., Sun B., Lu J.X.*, Liu C.*
    Proc. Natl. Acad. Sci. U S A.
    , 2021.  (¶co-first author, *corresponding author)
    Full Article
  • A novel partially-open state of SHP2 points to a "multiple gear" regulation 

    mechanism

    Tao Y.Q.¶, Xie J.F.¶, Zhong Q.L.¶, Wang Y.Y.¶, Zhang S.N, Luo F., Wen F.C., Xie J.J., 

    Zhao J.W., Sun X.O., Long H.F., Ma J.F., Zhang Q., Long J.G., Fang X.Y., Lu Y., Li D., Li M., Zhu J.D., Sun B., Li G.H.*, Diao J.J.*, Liu C.*

    J. Biol. Chem., 2021. (¶co-first author, *corresponding author)

    Full Article
  • Hierarchical chemical determination of amyloid polymorphs in 
    neurodegenerative disease
    Li D.*, Liu C.*
    Nat. Chem. Biol.
    , 2021. (*corresponding author)

    Full Article
2020
  • The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation 

    revealed by cryoEM structure

    Sun Y.P.¶, Zhao K.¶, Xia W.C., Feng G.Q., Gu J.G., Ma Y.Y., Gui X.R., Zhang X., 

    Fang Y.S., Sun B., Wang R.X., Liu C.*, Li D.*

    Nat. Commun., 2020. (¶co-first author, *corresponding author)
    Full Article
  • Hsp40 proteins phase separate to chaperone the assembly and maintenance of 

    membraneless organelles
    Gu J.G.¶, Liu Z,Y.¶, Zhang S.N., Li Y.C., Xia W.C., Wang C., Xiang H.J., Liu Z.J., Tan L., Fang Y.S., Liu C.*, Li D.*
    Proc. Natl. Acad. Sci. USA., 2020, 117(49), 31123-31133. 
    (¶co-first author, *corresponding author)

    Full Article
  • Phase separation of disease-associated SHP2 mutants underlies 
    MAPK hyperactivation
    Zhu G.Y.¶, Xie J.J.¶, Kong W.N.¶, Xie J.F.¶, Li Y.C., Du L., Zheng Q.G., Sun L., 
    Guan M.F., Li H., Zhu T.X., He H., Liu Z.Y., Xia X., Kan C., Tao Y.Q.,Shen H.C., Li D., 
    Wang S.Y., Yu Y.G., Yu Z.H., Zhang Z.Y., Liu C.*, Zhu J.D.*
    Cell,2020. (¶co-first author, *corresponding author)

    Full Article
  • Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein 
    amyloid fibril structure revealed by cryo-EM
    Zhao K.¶, Lim Y.J.¶, Liu Z.Y.¶, Long H.F., Sun Y.P., Hu J.J., Zhao C.Y., Tao Y.Q., 
    Zhang X., Li D., Li Y.M.*, Liu C.*
    Proc. Natl. Acad. Sci. USA.
    ,2020, 117(33), 20305-20315. 
    (¶co-first author, *corresponding author)
    Full Article
  • Liquid-liquid Phase Separation in Biology: Mechanisms, Physiological Functions 
    and Human Diseases
    Zhang H.*, Ji X.*, Li P.*, Liu C.*, Lou J.*, Wang Z., Wen W.*, Xiao Y., 
    Zhang M.*, Zhu X.*
    Sci. China. Life. Sci., 2020, 63, 953–985.(*corresponding author)
    Full Article
  • Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via 
    Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
    Wang C.¶, Duan Y.J.¶, Duan G.¶, Wang Q.Q., Zhang K., Deng X., QianB.T., Gu J.G., Ma Z.W., Zhang S., Guo L., Liu C.*, Fang Y.S.*
    Mol. Cell., 2020.(¶co-first author, *corresponding author)
    Full Article
  • Cryo-EM Structure of an Amyloid Fibril Formed by Full-Length 
    Human Prion Protein
    Wang L.Q.¶, Zhao K.¶, Yuan H.Y., Wang Q., Guan Z., Tao J., Li X.N., 
    Sun Y.P., Yi C.W., Chen J., Li D., Zhang D., Yin P., Liu C.*, Liang Y.*
    Nat. Struct. Mol. Biol., 2020, 27, 598–602.
    (¶co-first author, *corresponding author)
    Full Article
  • Parkinson’s disease associated mutation E46K of α-synuclein triggers 
    the formation of a distinct fibril structure
    Zhao K.¶, Li Y.W.¶, Liu Z.Y., Long H.F., Zhao C.Y., Luo F., Sun Y.P., Tao Y.Q., Su X.D., Li D.*,  Li X.M.*, Liu C.*
    Nat. Commun., 2020, 11, 2643. (¶co-first author, 
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  • Structural basis of the interplay between α-synuclein and Tau in 
    regulating pathological amyloid aggregation
    Lu J.X.¶, Zhang S.N.¶, Ma X.J.¶, Jia C.Y., Liu Z.Y., Huang C.A., Liu C.*, Li D.*
    J. Biol. Chem., 2020, bc.RA119.012284. (¶co-first author, 
    *corresponding author) 

    Full Article
  • Nicotinamide mononucleotide adenylyltransferase uses its 

    NAD+ substrate-binding site to chaperone phosphorylated Tau

    Ma X.J., Zhu Y., Lu J.X.,  J.F., Li C., Shin W.S., Qiang J.L, Liu J.Q., Dou S.,

    Xiao Y., Wang C.C., Jia C.Y., Long H.F., Yang J.T., Fang Y.S., Jiang L.,

    Zhang Y.Y., Zhang S.N., Zhai R.G.*, Liu C.*, Li D.*

    eLife., 2020;9:e51859 (¶co-first author, *corresponding author) 

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  • Hsp27 chaperones FUS phase separation under the modulation of 
    stress-induced phosphorylation
    Liu Z.Y.¶, Zhang S.N.¶, Gu J.G.¶, Tong Y.L., Li Y.C., Gui X.R., Long H.F., 
    Wang C.C., Zhao C.Y., Lu J.X., He L., Li Y., Liu Z.J.,  Li D.*, Liu C.*

    Nat. Struct. Mol. Biol., 2020, 27, 363–372.(¶co-first 

    author, *corresponding author)

    Full Article
  • Different regions of synaptic vesicle membrane regulate VAMP2 
    conformation for the SNARE assembly
    Wang C.C.¶, Tu J., Zhang S.N., Cai B., Liu Z.Y., Hou S.Q., Zhong Q.L., 
    Hu X., Liu W.B., Li G.H., Liu Z.J., He L., Diao J.J., Zhu Z.J.,  Li D.*, Liu C.*
    Nat. Commun.
    , 2020, 11, 1531.(¶first author, *corresponding author)
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  • Cryo-EM structure of full-length α-synuclein amyloid fibril with 
    Parkinson's disease familial A53T mutation
    Sun Y.P.¶, Hou S.Q.¶, Zhao K.¶, Long H.F., Liu Z.Y., Gao J., Zhang Y.Y.,
    Su X.D., Li D.*, Liu C.*

    Cell Research, 2020, 30, 360–362.(¶co-first author, *corresponding 

    author)

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  • Structural diversity of amyloid fibrils and advances in their structure 
    determination (Invited Perspective)
    Li D.*, Liu C.*
    Biochemistry
    , 2020, 59(5), 639-646.(*corresponding author) 
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2019
  • Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.
    Yu J., Liu Z.Z., Liang Y.Y., Luo F., Zhang J., Tian C.P., Motzik A. Zheng M.M., Kang J.w., Zhong G.S., Liu C., Fang P.F., Guo M., Razin E.*, Wang J.*
    Nat. Commun., 2019, 10, 4664(*corresponding author)
    Full Article
  • Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules.
    Zhou H., Luo F., Luo Z.P., Li D., Liu C.*, Li X.M.*
    Analytical Chemistry, 2019(*corresponding author)
    Full Article
  • Exploiting mammalian low-complexity domains for liquid-liquid phase separation–driven underwater adhesive coatings.
    Cui M.K., Wang X.Y., An B.L., Zhang C., Gui X.R., Li K., Li Y.F., Ge P., Zhang J.H., Liu C., Zhang C.*
    Science Advances, 2019, 5(8), eaax3155(*corresponding author)
    Full Article
  • Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
    Gui X.R., Luo F., Li Y.C., Zhou H., Qin Z.H., Liu Z.Y., Gu J.G., Xie M.Y., Zhao K., Dai B., Shin W.S., He J.H., He L., Jiang L., Zhao M.L., Sun B., Li X.M., Liu C.*, Li D.*
    Nat. Commun., 2019, 10(1), 2006(*corresponding author)
    Full Article
  • Modular genetic design of multi-domain functional amyloids: insights into self-assembly and functional properties.
    Cui M.K., Qi Q., Gurry T., Zhao T.X., An B., Pu J.H., Gui X.R., Cheng A.A., Zhang A.Y., Xun D.M., Becce M., Briatico-Vangosa F., Liu C., Lu T.K., Zhong C.
    Chem Sci, 2019, 10(14), 4004–4014
    Full Article
  • Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation
    Jia C.Y., Ma X.J., Liu Z.Y., Gu J.G., Zhang X., Li D.*, Zhang S.N.*
    Front. Neurosci., 2019, 13, 1124(*corresponding author)
    Full Article
  • Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation
    Lu J.X., Cao Q.,Wang C.C., Zheng J.,Luo F.,Xie J.F., Li Y.C.,Ma X.J., He L., Eisenberg D., Nowick J., Jiang L.*, Li D.*
    Front. Mol. Neurosci., 2019, 12, 54(*corresponding author)

    Full Article
  • Fibril Self-Assembly of Amyloid-Spider Silk Block Polypeptides.

    Dai B., Sargent C.J., Gui X.R., Liu C., Zhang F.

    Biomacromolecules, 2019

    Full Article
  • New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation. (Invited review)
    Liu C.*, Fang Y.*
    Biochem Pharmacol, 2019(*corresponding author)

    Full Article
  • Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET.
    Ma D.F., Xu C.H., Hou W.Q., Zhao C.Y., Ma J.B., Huang X.Y., Jia Q., Ma L., Diao J.J.,  Liu C.*, Li M.*, Lu Y.*
    Angew Chem Int Ed Engl, 2019,58(17), 5577-5581(* corresponding author)

    Full Article
  • PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.

    Duan Y.J., Du A.Y., Gu J.G., Duan G., Wang C., Gui X.R., Ma Z.W., Qian B.T., Deng X., Zhang K., Sun L., Tian K.L., Zhang Y.Y., Jiang H., Liu C.*, Fang Y.S.*

    Cell Research, 2019, 29, 233-247 (* corresponding author)

    Full Article
  • Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity.

    Zhang X., Zhang S.N., Zhang L., Lu J.X., Zhao C.Y., Luo F., Li D., Li X.M.*, Liu C.*

    J. Biol. Chem., 2019, 294(13), 4956-4965(* corresponding author)

    Full Article
2018
  • In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau.

    Zhang S.N.*, Wang C.C., Lu J.X., Ma X.J., Liu Z.Y., Li D., Liu Z.J., Liu C.*

    Int. J. Mol. Sci., 2018, 20(1), 90 (*corresponding author)

    Full Article
  • Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization.

    Liu Z.Y., Wang C.C., Li Y.C., Zhao C.Y., Li T.Z., Li D., Zhang S.N.*, Liu C.*

    J. Biol. Chem., 2018, 293(38):14880-14890 (* corresponding author)

    Full Article
  • Amyloid fibril structure of α-synuclein determined by cryoelectron microscopy.

    Li Y.W.¶, Zhao C.Y.¶, Luo F.¶, Liu Z.Y., Gui X.R., Luo Z.P., Zhang X., Li D.*, Liu C.*, Li X.M.*

    Cell Research, 2018, 28, 897-903 (* corresponding author)

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  • Better Together: A Hybrid Amyloid Signals Necroptosis. (Invited preview)

    Li D.*, Liu C.*

    Cell, 2018, 173, 1068-1070. (* corresponding author)

    Full Article
  • Atomic structures of two segments from FUS LC domain reveal reversible amyloid fibril formation.

    Luo F.¶, Gui X.R.¶, Zhou H.¶, Gu J.G., Li Y.C., Liu X.Y., Zhao M.L., Li D.*, Li X.M.* and Liu C.*

    Nat. Struct. Mol. Biol., 2018, 25, 341-346. (* corresponding author)

    Full Article
2017
  • Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.

    Xie J.J., Si X.J., Gu S.L., Wang M.L., Shen J., Li H.Y., Shen J., Li D., Fang Y.J., Liu C.* and Zhu J.D.*

    Journal of Medicinal Chemistry, 2017, 60, 10205-10219. (* corresponding author)

    Full Article
  • N-Terminal Acetylation Preserves α-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds.

    Bu B., Tong X., Li D., Hu Y., He W., Zhao C., Hu R., Li X., Shao Y., Liu C., Zhao Q., Ji B., and Diao J.

    ACS Chem Neurosci., 2017, 18, 2145-2151.

    Full Article
  • Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.

    An B.L., Wang X.Y., Cui M.K., Gui X.R., Mao X.H., Liu Y., Li K., Chu C.F., Pu J.H., Ren S.S., Wang Y.Y., Zhong G.S., Lu T.K., Liu C. and Zhong C. 

    ACS Nano, 2017, 11:6985-6995.

    Full Article
  • A structural view of αB-crystallin assembly and amyloid aggregation. (Invited review)

    Liu Z.Y., Zhang S.N., Li D., and  Liu C.*

    Protein & Peptide Letters, 2017, 24, 1-7. (* corresponding author)

    Full Article
2016
  • Versatile structures of a-Synuclein. (Invited review)

    Wang C.C., Zhao C.Y., Li D., Tian Z.Q., Lai Y., Diao J.J.*, Liu C.*

    Frontiers in Molecular Neuroscience, 2016, 9, 48. (* corresponding author)

    Full Article
  • Precise and reversible protein microtubule-like structure with helicity driven by dual supramolecular interactions

    Yang G., Zhang X., Kochovshi Z., Zhang Y., Dai B., Sakai F., Jiang L., Lu Y., Ballauff M., Li X., Liu C.*, Chen G.*, Jiang M. 

    J. Am. Chem. Soc., 2016, 138, 1932-1937. (* corresponding author)

    Full Article
2015
  • Tunable assembly of amyloid-forming prptides into nanosheets as a retrovirus carrier.

    Dai B.¶, Li D.¶, Xi W.H., Luo F., Zhang X., Zou M., Cao M., Hu J., Wang W.Y., Wei G.H.*, Zhang Y.*, Liu C.*

    Proc. Natl. Acad. Sci. USA., 2015, 112, 2996-3001. (* corresponding author)


    Full Article
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