Publications-LIU LAB

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
Hu J.J.¶, Xia W.C.¶, Zeng S.Y.¶, Lim Y.J.¶, Tao Y.Q., Sun Y.P., Zhao L., Wang H.S.,
Le W.D., Li D., Zhang S.N., Liu C.*, Li Y.M.*
Nat Commun., 2024. (¶co-first author, *corresponding author)
Full Article
Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus
Zhang H.¶, Guo H.Z., Li D.N., Zhang Y.L., Zhang S.Q., Kang W.Y., Liu C., Le W.D.,
Wang L.*, Li D.*, Dai B.*
Nat Commun., 2024. (¶co-first author, *corresponding author)
Full Article
N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
Wang C.¶, Zhao C.¶, Hu X., Qiang J., Liu Z., Gu J., Zhang S., Li D., Zhang Y., Burré J., Diao J.*, Liu C.*
bioRxiv., 2024. (¶co-first author, *corresponding author)
Full Article
Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions
Hou S.¶, Hu J.J.¶, Yu Z.W., Li D, Liu C.*, Zhang Y.*
Nat Commun., 2024. (¶co-first author, *corresponding author)
Full Article
Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies
Zhao W.B.¶, Liu K.E.¶, Fan Y.¶, Zhao Q.Y., Tao Y.Q., Zhang M.W., Gan L.H., Yu W.B.,
Sun B., Li D., Liu C.*, Wang J.*
Cell Discov., 2024. (¶co-first author, *corresponding author)
Full Article
Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure
Jiang Y.Q.¶, Gu J.G.¶, Niu X.D.¶, Hu J.J., Zhang Y.Z., Li D., Tang Y.D., Liu C.*, Li Z.J.*
Circulation., 2024. (¶co-first author, *corresponding author)
Full Article

Advanced Techniques for Detecting Protein Misfolding and Aggregation in
Cellular Environments
Bai Y.L.¶, Zhang S.N.¶, Dong H.¶, Liu Y., Liu C.*, Zhang X.*
Chem Rev., 2023. (¶co-first author, *corresponding author)
Full Article
Molecular rules governing the structural polymorphism of amyloid fibrils in
neurodegenerative diseases
Li D.*, Liu C.*
Structure., 2023. (*corresponding author)
Full Article
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle
clustering
Lai Y.¶, Zhao C.Y.¶, Tian Z.Q.¶, Wang C.C.¶, Fan J.Q.¶, Hu X., Tu J., Li T.H.,
Leitz Jeremy., Pfuetzne R.A., Liu Z.T., Zhang S.N., Su Z.M., Burré J., Li D.,
Südhof Thomas.C., Zhu Z.J., Liu C.*, Brunger Axel.T.*, Diao J.J.*
Proc Natl Acad Sci U S A., 2023. (¶co-first author, *corresponding author)
Full Article
Creating an Amyloid 'Kaleidoscope' Using Short Iodinated Peptides
Li D.N.¶, Ma Y.Y.¶, Xia W.C., Tao Y.Q., Zhang Y.L., Zhang H., Li D., Dai B.*, Liu C.*
Angew Chem Int Ed Engl., 2023. (¶co-first author, *corresponding author)
Full Article
Engineering of antimicrobial peptide fibrils with feedback degradation of
bacterial-secreted enzymes
Wang F.H.¶, Xia W.C.¶, Zhang M.M., Wu R.R., Song X.L., Hao Y., Feng Y.H.,
Zhang L.W., Li D., Kang W.Y., Liu C.*, Liu L.*
Chem Sci., 2023. (¶co-first author, *corresponding author)
Full Article
Rational design of functional amyloid fibrillar assemblies
Wang X.Y.¶, Zhang S.N.¶, Zhang J.C., Wang Y.M., Jiang X.Y., Tao Y.Q., Li D.,
Zhong C.*, Liu C.*
Chem Soc Rev., 2023. (¶co-first author, *corresponding author)
Full Article
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
Xiang J.¶, Tao Y.Q.¶, Xia Y.Y.¶, Luo S.L., Zhao Q.Y., Li B.W., Zhang X.Q., Sun Y.P., Xia W.C., Zhang M.M., Kang S.S., Ahn E.H., Liu X., Xie F., Guan Y.H., Yang J.J., Bu L,H., Wu S.X., Wang X.C., Cao X.B., Liu C., Zhang Z.T.*, Li D.*, Ye K.Q.*
Cell., 2023. (¶co-first author, *corresponding author)
Full Article
Structural mechanism for specific binding of chemical compounds to amyloid
fibrils
Tao Y.Q.¶, Xia W.C.¶, Zhao Q.Y.¶, Xiang H.J., Han C., Zhang S.Q., Gu W.,
Tang W.J, Li Y., Tan L., Li D.*, Liu C.*
Nat Chem Biol., 2023. (¶co-first author, *corresponding author)
Full Article
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology
and cognitive deficits in Alzheimer's disease model mice
Zhao Y.N.¶, Zheng Q.Y., Hong Y.J., Gao Y., Hu J.J., Lang M.J., Zhang H.F., Zhou Y.,
Luo H., Zhang X., Sun H., Yan X.X., Huang T., Wang Y.J., Xu H., Liu C., Wang X.*
Nat Neurosci., 2023. (¶co-first author, *corresponding author)
Full Article
Protein amyloid aggregate: Structure and function
Xu Q.H.¶, Ma Y.Y.¶, Sun Y.P.¶, Li D., Zhang X., Liu C.*
Aggregate., 2023. (¶co-first author, *corresponding author)
Full Article
Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions
in nucleocapsid-like assembly
Wang Y.¶, Ling X.B.¶, Zhang C., Zou J., Luo B.N., Luo Y.B., Jia X.Y., Jia G.W.,
Zhang M.H., Hu J.C., Liu T., Wang Y.F.Y., Lu K.F., Li D., Ma J.B.*, Liu C.*, Su Z.M.*
Mol Biomed., 2023. (¶co-first author, *corresponding author)
Full Article
Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent
Abnormal Phase Transition of Fused in Sarcoma Protein
Zhang H.¶, Gu J.G., Zhang Y.L., Guo H.Z., Zhang S.N., Song J., Liu C., Wang L.*,
Li D.*, Dai B.*
ACS Nano., 2023. (¶co-first author, *corresponding author)
Full Article
Emerging roles of O-glycosylation in regulating protein aggregation, phase
separation, and functions
Li X.¶, Lv P.¶, Du Y.F.¶, Xing C.*, Liu C.*
Curr Opin Chem Biol., 2023. (¶co-first author, *corresponding author)
Full Article
Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding
Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based
Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy
Zhang S.N.¶, Li J.¶, Xu Q.H.¶, Xia W.C., Tao Y.Q., Shi C.W., Li D., Xiang S.Q.*, Liu C.*
J Am Chem Soc., 2023. (¶co-first author, *corresponding author)
Full Article
Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis
elegans
Wang F.R.¶, Jin T.¶, Li H.Y.¶, Long H.F., Liu Y., Jin S., Lu Y.Y., Peng Y.H., Liu C.,
Zhao L.H.*, Wang X.H.*
FASEB J., 2023. (¶co-first author, *corresponding author)
Full Article
Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates
α-synucleinopathy in rat brain
Yang Z.F.¶, Wang Y.¶, Wei M., Li S., Jia C.C., Cheng C., Nusaif M., Zhang J., Liu C.,
Le W.D.*
Cell Death Dis., 2023. (¶co-first author, *corresponding author)
Full Article

Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases
Zhang S.Q.¶, Dong H.¶, Bian J.¶, Li D., Liu C.*
Fundamental Research., 2022. (¶co-first author, *corresponding author)
Full Article
Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease
Fan Y.¶, Sun Y.P.¶, Yu W.B., Tao Y.Q., Xia W.C., Liu Y.Q., Zhao Y.Q., Tang Y.L., Sun Y.M., Liu F.T., Cao Q., Wu J.J., Liu C., Wang J.*, Li D.*
Structure., 2022. (¶co-first author, *corresponding author)
Full Article
Subtle change of fibrillation condition leads to substantial alteration of
recombinant Tau fibril structure
Li X.¶, Zhang S.Q.¶, Liu Z.T.¶, Tao Y.Q., Xia W.C., Sun Y.P., Liu C., Le W.D., Sun B.,
Li D.*
iScience., 2022. (¶co-first author, *corresponding author)
Full Article
Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular
integrity and mitigates acute lung injury
He H.¶, Yang W.¶, Su N.¶, Zhang C.K., Dai J.N., Han F., Singhai M., Bai W.J., Zhu X.L., Zhu J., Liu Z., Xia W.C., Liu X.T., Zhang C.H., Jiang K., Huang W.H., Chen D.,
Wang Z.Y., He X.Y., Kirchhoff F., Li Z.Y., Liu C., Huan J.N., Wang X.H., Wei W.,
Wang J., Augustin H.G., Hu J.H.*
J Exp Med., 2023. (¶co-first author, *corresponding author)
Full Article
Global profiling of arginine dimethylation in regulating protein phase separation
by a steric effect-based chemical-enrichment method
Wang Q.¶, Li Z.X.¶, Zhang S.Q.¶, Li Y.C., Wang Y., Fang Z., Ma Y.N., Liu Z., Li D.,
Liu C.*, Ye M.L.*
Proc. Natl. Acad. Sci. U S A., 2022. (¶co-first author, *corresponding author)
Full Article
A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation
Li Y.C., Gu J.G., Liu C., Li D.*
Methods in Molecular Biology., 2022 (*corresponding author)
Full Article
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of
microglia
Long H.F.¶, Zhang S.N.¶, Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*
Cell Rep., 2022. (¶co-first author, *corresponding author)
Full Article
Non-ergodicity of a globular protein extending beyond its functional timescale
Li J.¶, Xie J.F., Godec A., Weninger K.R., Liu C., Smith J.C., Hong L.*
Chem Sci., 2022. (¶co-first author, *corresponding author)
Full Article
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation
and liquid-to-gel transition
Lu S.¶, Hu J.J., Arogundade O.A., Goginashvili A., Vazquez-Sanchez S., Diedrich J.K., Gu J.G., Blum J., Oung S., Ye Q.Z., Yu H.Y., Ravits J., Liu C., Yates J.R.,
Cleveland D.W.*
Nat Cell Biol. 2022. (¶co-first author, *corresponding author)
Full Article
Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau
aggregation-induced pathology
Zhang S.N.¶, Zhu Y.¶, Lu J.X.¶, Liu Z.Y., Lobato A.G., Zeng W., Liu J.Q., Zeng S.Y.,
Liu C., Liu J., He Z.H., Zhai R.G.*, Li D.*
Elife., 2022. (¶co-first author, *corresponding author)
Full Article
Bloom Syndrome Helicase Compresses Single‐Stranded DNA into
Phase‐Separated Condensates
Wang T.¶, Hu J.J.¶, Li Y.N., Bi L.L., Guo X.S., Zhang X., Li D., Hou X.M., Modesti M.,
Xi X.G., Liu C.*, Sun B.*
Angew Chem Int Ed Engl., 2022. (¶co-first author, *corresponding author)
Full Article
Stochastically multimerized ParB orchestrates DNA assembly as unveiled by
single-molecule analysis
Guo J.L.¶, Zhao Y.L.¶, Zhang Q., Feng Y., Zhang X., Wang T., Liu C., Ma H.H., Sun B.*
Nucleic Acids Res., 2022. (¶co-first author, *corresponding author)
Full Article
Heparin induces α-synuclein to form new fibril polymorphs with attenuated
neuropathology
Tao Y.Q.¶, Sun Y.P.¶, Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y.,
Liu C.*, Li D.*
Nat Commun., 2022. (¶co-first author, *corresponding author)
Full Article
Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related
proteins in the nucleus
Gao C.¶, Gu J.G., Zhang H., Jiang K., Tang L.L., Liu R., Zhang L., Zhang P.F., Liu C.*,
Dai B.*, Song H.*
Cell Reports., 2022. (¶first author, *corresponding author)
Full Article
Structural insights of Fe 3+ induced α-synuclein fibrillation in Parkinson's disease
Zhao Q.Y.¶, Tao Y.Q.¶, Zhao K., Ma Y.Y., Xu Q.H., Liu C., Zhang S.N., Li D.*
J Mol Biol., 2022. (¶co-first author, *corresponding author)
Full Article
Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion
Wang L.Q.¶, Ma Y.Y.¶, Yuan H.Y.¶, Zhao K., Zhang M.Y., Wang Q., Huang X., Dai B.,
Chen J., Li D., Zhang D.L., Wang Z.Z., Zou L.Y., Yin P., Liu C.*, Liang Y.*
Nat. Commun., 2022. (¶co-first author, *corresponding author)
Full Article
Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation
Li Y.C.¶, Gu J.G., Wang C., Hu J.J., Zhang S.Q., Liu C., Zhang S.N., Fang Y.S., Li D.*
iScience., 2022. (¶co-first author, *corresponding author)
Full Article
Conformational strains of pathogenic amyloid proteins in neurodegenerative
diseases
Li D.*, Liu C.*
Nat Rev Neurosci., 2022. (*corresponding author)
Full Article
Cellular and animal models to investigate pathogenesis of amyloid aggregation
in neurodegenerative diseases
Long H.F., Zeng S.Y., Li D.*
Biophysics Reports., 2022. (*corresponding author)
Full Article
Biochemical and biophysical characterization of pathological aggregation of
amyloid proteins
Long H.F., Zeng S.Y., Sun Y.P., Liu C.*
Biophysics Reports., 2022. (*corresponding author)
Full Article
Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation
Song Y.X., Dai B., Wang Y., Wang Y., Liu C., Gourdon P., Liu L.*, Wang K.T.*,
Dong M.D.*
Nano Lett., 2022. (*corresponding author)
Full Article
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance
in Arabidopsis
Zhu S.B.¶, Gu J.G.¶, Yao J.J., Li Y.C., Zhang Z.T., Xia W.C., Wang Z., Gui X.R., Li L.T.,
Li D., Zhang H.*, Liu C.*
Developmental Cell., 2022. (¶co-first author, *corresponding author)
Full Article
A high-throughput method for exploring the parameter space of protein
liquid-liquid phase separation
Li Y.C.¶, Gu J.G.¶, Liu C.*, Li D.*
Cell Reports Physical Science., 2022 (¶co-first author, *corresponding author)
Full Article
SARS-CoV-2 impairs the disassembly of stress granules and promotes
ALS-associated amyloid aggregation
Li Y.C.¶, Lu S.Y.¶, Gu J.G.¶, Xia W.C., Zhang S.N., Zhang S.Q., Wang Y., Zhang C.,
Sun Y.P., Lei J., Liu C., Su Z.M.*, Yang J.T.*, Peng X.Z.*, Li D.*
Protein Cell., 2022. (¶co-first author, *corresponding author)
Full Article
The mouse nicotinamide mononucleotide adenylyltransferase chaperones
diverse pathological amyloid client proteins
Huang C.A.¶, Lu J.X.¶, Ma X.J.¶, Qiang J.L., Wang C.C., Liu C., Fang Y.S., Zhang Y.Y.,
Li D.*, Zhang S.N.*
J Biol Chem., 2022. (¶co-first author, *corresponding author)
Full Article
Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease
dementia and normal elders
Fan Y.¶, Zhao Q.Y.¶, Xia W.C.¶, Tao Y.Q., Yu W.B., Chen M.J., Liu Y.Q., Zhao J.,
Sun Y.P., Si C.F., Zhang S.Q., Zhang Y.Y., Li W.S., Liu C.*, Wang J.*, Li D.*
Cell Research., 2022. (¶co-first author, *corresponding author)
Full Article
Spatiotemporal dynamic regulation of membraneless organelles by chaperone
networks
Li D.*, Liu C.*
Trends in Cell Biology., 2022. (*corresponding author)
Full Article

Molecular structure of an amyloid fibril formed by FUS low-complexity domain
Sun Y.P.¶, Zhang S.Q.¶, Hu J.J.¶, Tao Y.Q., Xia W.C., Gu J.G., Li Y.C., Cao Q., Li D.,
Liu C.*
iScience., 2021. (¶co-first author, *corresponding author)
Full Article
Genetic prion disease–related mutation E196K displays a novel amyloid fibril
structure revealed by cryo-EM
Wang L.Q.¶, Zhao K.¶, Yuan H.Y.¶, Dang H.B., Ma Y.Y., Wang Q., Wang C., Sun Y.P., Chen J., Li D., Zhang D.L., Yin P., Liu C.*, Liang Y.*
Science Advances., 2021. (¶co-first author, *corresponding author)
Full Article
The hereditary mutation G51D unlocks a distinct fibril strain transmissible to
wild-type α-synuclein
Sun Y.P.¶, Long H.F.¶, Xia W.C., Wang K., Zhang X., Sun B., Cao, Q., Zhang Y.Y.,
Dai B., Li D., Liu C.*
Nat. Commun., 2021. (¶co-first author, *corresponding author)
Full Article
O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable
for Degradation
Liu D.L.¶, Wei Q.J.¶, Xia W.C.¶, He C.D., Zhang Q.K., Huang L., Wang X.Y., Sun Y.P.,
Ma Y.Y., Zhang X.H., Wang Y., Shi X.M., Liu C.*, Dong S.W.*
J. Am. Chem. Soc., 2021. (¶co-first author, *corresponding author)
Full Article
Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from
amyloid aggregation
Gu J.G.¶, Wang C.¶, Hu R.F.¶, Li Y.C., Zhang S.N., Sun Y.P., Wang Q.Q., Li D.,
Fang Y.S.*, Liu C.*
Cell Research., 2021. (¶co-first author, *corresponding author)
Full Article
Mechanistic basis for receptor-mediated pathological α-synuclein fibril
cell-to-cell transmission in Parkinson's disease
Zhang S.N.¶, Liu Y.Q.¶, Jia C.Y.¶, Lim Y.J.¶, Feng G.Q.¶, Xu E.Q., Long H.F.,
Yasuyoshi Kimura, Tao Y.Q., Zhao C.Y., Wang C.C., Liu Z.Y., Hu J.J., Ma M.R.,
Liu Z.J., Lin J., Li D., Wang R.X., Valina L Dawson, Ted M Dawson*, Li Y.M.*,
Mao X.B.*, Liu C.*
Proc. Natl. Acad. Sci. U S A., 2021. (¶co-first author, *corresponding author)
Full Article
Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding
Long H.F.¶, Zheng W.T.¶, Liu Y., Sun Y.P., Zhao K., Liu Z.Y., Xia W.C., Lv S.R., Liu Z.T., Li D., He K.W.*, Liu C.*
Proc. Natl. Acad. Sci. U S A., 2021. (¶co-first author, *corresponding author)
Full Article
The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3
Wu X.L.¶, Ma Y.Y.¶, Zhao K.¶, Zhang J., Sun Y.P., Li Y.C., Dong X.Q., Hu H., Liu J.,
Wang J., Zhang X., Li B., Wang H.Y., Li D., Sun B., Lu J.X.*, Liu C.*
Proc. Natl. Acad. Sci. U S A., 2021. (¶co-first author, *corresponding author)
Full Article
A novel partially-open state of SHP2 points to a "multiple gear" regulation
mechanism
Tao Y.Q.¶, Xie J.F.¶, Zhong Q.L.¶, Wang Y.Y.¶, Zhang S.N, Luo F., Wen F.C., Xie J.J.,
Zhao J.W., Sun X.O., Long H.F., Ma J.F., Zhang Q., Long J.G., Fang X.Y., Lu Y., Li D., Li M., Zhu J.D., Sun B., Li G.H.*, Diao J.J.*, Liu C.*
J. Biol. Chem., 2021. (¶co-first author, *corresponding author)
Full Article
Hierarchical chemical determination of amyloid polymorphs in
neurodegenerative disease
Li D.*, Liu C.*
Nat. Chem. Biol., 2021. (*corresponding author)
Full Article

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation
revealed by cryoEM structure
Sun Y.P.¶, Zhao K.¶, Xia W.C., Feng G.Q., Gu J.G., Ma Y.Y., Gui X.R., Zhang X.,
Fang Y.S., Sun B., Wang R.X., Liu C.*, Li D.*
Nat. Commun., 2020. (¶co-first author, *corresponding author)
Full Article
Hsp40 proteins phase separate to chaperone the assembly and maintenance of
membraneless organelles
Gu J.G.¶, Liu Z,Y.¶, Zhang S.N., Li Y.C., Xia W.C., Wang C., Xiang H.J., Liu Z.J., Tan L., Fang Y.S., Liu C.*, Li D.*
Proc. Natl. Acad. Sci. USA., 2020, 117(49), 31123-31133.
(¶co-first author, *corresponding author)
Full Article
Phase separation of disease-associated SHP2 mutants underlies
MAPK hyperactivation
Zhu G.Y.¶, Xie J.J.¶, Kong W.N.¶, Xie J.F.¶, Li Y.C., Du L., Zheng Q.G., Sun L.,
Guan M.F., Li H., Zhu T.X., He H., Liu Z.Y., Xia X., Kan C., Tao Y.Q.,Shen H.C., Li D.,
Wang S.Y., Yu Y.G., Yu Z.H., Zhang Z.Y., Liu C.*, Zhu J.D.*
Cell,2020. (¶co-first author, *corresponding author)
Full Article
Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein
amyloid fibril structure revealed by cryo-EM
Zhao K.¶, Lim Y.J.¶, Liu Z.Y.¶, Long H.F., Sun Y.P., Hu J.J., Zhao C.Y., Tao Y.Q.,
Zhang X., Li D., Li Y.M.*, Liu C.*
Proc. Natl. Acad. Sci. USA.,2020, 117(33), 20305-20315.
(¶co-first author, *corresponding author)
Full Article
Liquid-liquid Phase Separation in Biology: Mechanisms, Physiological Functions
and Human Diseases
Zhang H.*, Ji X.*, Li P.*, Liu C.*, Lou J.*, Wang Z., Wen W.*, Xiao Y.,
Zhang M.*, Zhu X.*
Sci. China. Life. Sci., 2020, 63, 953–985.(*corresponding author)
Full Article
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via
Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
Wang C.¶, Duan Y.J.¶, Duan G.¶, Wang Q.Q., Zhang K., Deng X., QianB.T., Gu J.G., Ma Z.W., Zhang S., Guo L., Liu C.*, Fang Y.S.*
Mol. Cell., 2020.(¶co-first author, *corresponding author)
Full Article
Cryo-EM Structure of an Amyloid Fibril Formed by Full-Length
Human Prion Protein
Wang L.Q.¶, Zhao K.¶, Yuan H.Y., Wang Q., Guan Z., Tao J., Li X.N.,
Sun Y.P., Yi C.W., Chen J., Li D., Zhang D., Yin P., Liu C.*, Liang Y.*
Nat. Struct. Mol. Biol., 2020, 27, 598–602.
(¶co-first author, *corresponding author)
Full Article
Parkinson’s disease associated mutation E46K of α-synuclein triggers
the formation of a distinct fibril structure
Zhao K.¶, Li Y.W.¶, Liu Z.Y., Long H.F., Zhao C.Y., Luo F., Sun Y.P., Tao Y.Q., Su X.D., Li D.*, Li X.M.*, Liu C.*
Nat. Commun., 2020, 11, 2643. (¶co-first author,
*corresponding author)
Full Article
Structural basis of the interplay between α-synuclein and Tau in
regulating pathological amyloid aggregation
Lu J.X.¶, Zhang S.N.¶, Ma X.J.¶, Jia C.Y., Liu Z.Y., Huang C.A., Liu C.*, Li D.*
J. Biol. Chem., 2020, bc.RA119.012284. (¶co-first author,
*corresponding author)
Full Article
Nicotinamide mononucleotide adenylyltransferase uses its
NAD+ substrate-binding site to chaperone phosphorylated Tau
Ma X.J.¶, Zhu Y.¶, Lu J.X., J.F., Li C., Shin W.S., Qiang J.L, Liu J.Q., Dou S.,
Xiao Y., Wang C.C., Jia C.Y., Long H.F., Yang J.T., Fang Y.S., Jiang L.,
Zhang Y.Y., Zhang S.N., Zhai R.G.*, Liu C.*, Li D.*
eLife., 2020;9:e51859 (¶co-first author, *corresponding author)
Full Article
Hsp27 chaperones FUS phase separation under the modulation of
stress-induced phosphorylation
Liu Z.Y.¶, Zhang S.N.¶, Gu J.G.¶, Tong Y.L., Li Y.C., Gui X.R., Long H.F.,
Wang C.C., Zhao C.Y., Lu J.X., He L., Li Y., Liu Z.J., Li D.*, Liu C.*
Nat. Struct. Mol. Biol., 2020, 27, 363–372.(¶co-first
author, *corresponding author)
Full Article
Different regions of synaptic vesicle membrane regulate VAMP2
conformation for the SNARE assembly
Wang C.C.¶, Tu J., Zhang S.N., Cai B., Liu Z.Y., Hou S.Q., Zhong Q.L.,
Hu X., Liu W.B., Li G.H., Liu Z.J., He L., Diao J.J., Zhu Z.J., Li D.*, Liu C.*
Nat. Commun., 2020, 11, 1531.(¶first author, *corresponding author)
Full Article
Cryo-EM structure of full-length α-synuclein amyloid fibril with
Parkinson's disease familial A53T mutation
Sun Y.P.¶, Hou S.Q.¶, Zhao K.¶, Long H.F., Liu Z.Y., Gao J., Zhang Y.Y.,
Su X.D., Li D.*, Liu C.*
Cell Research, 2020, 30, 360–362.(¶co-first author, *corresponding
author)
Full Article
Structural diversity of amyloid fibrils and advances in their structure
determination (Invited Perspective)
Li D.*, Liu C.*
Biochemistry, 2020, 59(5), 639-646.(*corresponding author)
Full Article

Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells.
Yu J., Liu Z.Z., Liang Y.Y., Luo F., Zhang J., Tian C.P., Motzik A. Zheng M.M., Kang J.w., Zhong G.S., Liu C., Fang P.F., Guo M., Razin E.*, Wang J.*
Nat. Commun., 2019, 10, 4664(*corresponding author)
Full Article
Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules.
Zhou H., Luo F., Luo Z.P., Li D., Liu C.*, Li X.M.*
Analytical Chemistry, 2019(*corresponding author)
Full Article
Exploiting mammalian low-complexity domains for liquid-liquid phase separation–driven underwater adhesive coatings.
Cui M.K., Wang X.Y., An B.L., Zhang C., Gui X.R., Li K., Li Y.F., Ge P., Zhang J.H., Liu C., Zhang C.*
Science Advances, 2019, 5(8), eaax3155(*corresponding author)
Full Article
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Gui X.R., Luo F., Li Y.C., Zhou H., Qin Z.H., Liu Z.Y., Gu J.G., Xie M.Y., Zhao K., Dai B., Shin W.S., He J.H., He L., Jiang L., Zhao M.L., Sun B., Li X.M., Liu C.*, Li D.*
Nat. Commun., 2019, 10(1), 2006(*corresponding author)
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